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Mitochondrial Transplantation promotes protective effector and memory CD4 <sup>+</sup> T cell response during <i>Mycobacterium tuberculosis</i> infection and diminishes exhaustion and senescence in elderly CD4 <sup>+</sup> T cells

2024-01-27

Abstract excerpt

Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis ( M.tb ), remains a significant health concern worldwide, especially in populations with weakened or compromised immune systems, such as the elderly. Proper adaptive immune function, particularly a CD4 + T cell response, is central to host immunity against M.tb . Chronic infections, such as M.tb , as well as aging promote T cell exhaustion...

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Literature Corpus work
01b4d92e-8d2c-5a45-b681-46187cf0aea8
DOI
10.1101/2024.01.24.577036
Open publication

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Mitochondrial Transplantation promotes protective effector and memory CD4 <sup>+</sup> T cell response during <i>Mycobacterium tuberculosis</i> infection and diminishes exhaustion and senescence in elderly CD4 <sup>+</sup> T cellsDOI 10.1101/2024.01.24.577036
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