Article

Mitochondrial mass governs the extent of T cell senescence

2019-05-04

Abstract excerpt

The susceptibility of human CD4 + and CD8 + T cells to senesce differs, with CD8 + T cells acquiring an immunosenescent phenotype faster than their CD4 + T cell compartment. We show here that it is the inherent difference in mitochondrial content that drives this phenotype, with senescent human CD4 + T cells displaying a higher mitochondrial mass. The loss of mitochondria in the senescent human CD8 + T cells...

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Literature Corpus work: 37d772bb-790a-5545-bede-cbeae89e2f3c
DOI: 10.1101/627240

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