Mitochondria are required for pro-ageing features of the senescent phenotype.

doi:10.15252/embj.201592862

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Article

Mitochondria are required for pro-ageing features of the senescent phenotype.

The EMBO journal - 1 Apr 2016

Correia-Melo Clara, Marques Francisco D M, Anderson Rhys, Hewitt Graeme, Hewitt Rachael, Cole John, Carroll Bernadette M, Miwa Satomi, Birch Jodie, Merz Alina, Rushton Michael D, Charles Michelle, Jurk Diana, Tait Stephen W G, Czapiewski Rafal, Greaves Laura, Nelson Glyn, Bohlooly-Y Mohammad, Rodriguez-Cuenca Sergio, Vidal-Puig Antonio, Mann Derek, Saretzki Gabriele, Quarato Giovanni, Green Douglas R, Adams Peter D, von Zglinicki Thomas, Korolchuk Viktor I, Passos João F

Abstract excerpt

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both functions are dependent on the development of the senescent phenotype, which involves an overproduction of pro-inflammatory and pro-oxidant signals. However, the exact mechanisms regulating these phenotypes remain poorly understood. Here, we show the critical role of mitochondria in cellular senescence. In multiple models of...

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PMID: 26848154
DOI: 10.15252/embj.201592862
PMCID: PMC4818766

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