Article

Linked regulation of genome integrity and senescence-associated inflammation by p53

2023-11-21

Abstract excerpt

Genomic instability and inflammation are distinct hallmarks of aging, but the connection between them is poorly understood. Understanding their interrelationship will help unravel new mechanisms and therapeutic targets of aging and age-associated diseases. Here we report a novel mechanism directly linking genomic instability and inflammation in senescent cells through a mitochondria-regulated molecular circuit dri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da047ff8-a3d9-5f0a-89f8-068fec3699f1
DOI: 10.1101/2023.11.20.567963

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Linked regulation of genome integrity and senescence-associated inflammation by p53DOI 10.1101/2023.11.20.567963Read

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cellsSemantic proximity Read

Mitochondrial DNA: Bridging cellular senescence and chronic inflammation in aging and beyond.Semantic proximity Read

Toward understanding genomic instability, mitochondrial dysfunction and agingSemantic proximity Read

Oxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic HorizonsSemantic proximity Read

Non-Genomic Hallmarks of Aging—The ReviewSemantic proximity Read

Mitochondria are required for pro-ageing features of the senescent phenotype.Semantic proximity Read

The senescent cell epigenomeSemantic proximity Read

Apoptotic stress causes mtDNA release during senescence and drives the SASP.Semantic proximity Read

DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-agingSemantic proximity Read

Interrogating the regulatory epigenome of cellular senescenceSemantic proximity Read

Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional DeclineSemantic proximity Read

Recent Advances in Anti‐Aging Therapeutic Strategies Targeting DNA Damage Response and Senescence‐Associated Secretory Phenotype‐Linked Signaling CascadeSemantic proximity Read