Article

Generation of Somatic Mitochondrial DNA-Replaced Cells for Mitochondrial Dysfunction Treatment

2020-10-01

Abstract excerpt

Mitochondrial diseases currently have no cure regardless of whether the cause is a nuclear or mitochondrial genome mutation. Mitochondrial dysfunction notably affects a wide range of disorders in aged individuals, including neurodegenerative diseases, cancers, and even senescence. Here, we present a procedure to generate mitochondrial DNA-replaced somatic cells with a combination of a temporal reduction in endogen...

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Literature Corpus work: 56e6dc4f-f55b-5811-9d0e-39ea9b6dbbbc
DOI: 10.1101/2020.10.01.321851

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