Article
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
Cell metabolism - 9 Feb 2016
Wiley Christopher D, Velarde Michael C, Lecot Pacome, Liu Su, Sarnoski Ethan A, Freund Adam, Shirakawa Kotaro, Lim Hyung W, Davis Sonnet S, Ramanathan Arvind, Gerencser Akos A, Verdin Eric, Campisi Judith
Abstract excerpt
Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function can drive age-related declines in the function of many post-mitotic tissues, but little is known about how mitochondrial dysfunction affects mitotic tissues. We show here that several manipulations that compromise mitochondrial function...
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