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Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix

25 Nov 2010

Abstract excerpt

Human diploid fibroblasts have the capacity to complete a finite number of cell divisions before entering a state of replicative senescence characterized by growth arrest, changes in morphology, and altered gene expression. Herein, we report that interaction with extracellular matrix (ECM) from young cells is sufficient to restore aged, senescent cells to an apparently youthful state. The identity of the restored...

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PMID: 21108727
DOI: 10.1111/j.1474-9726.2010.00654.x

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