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BESTish: A Diffusion-Approximation Framework for Inferring Selection and Mutation in Clonal Hematopoiesis

2026-01-29

Abstract excerpt

Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) gain a fitness advantage from somatic mutations and expand, resulting in an increase in variant allele frequency (VAF) over time. To analyze CH trajectories, we develop a state-dependent stochastic model of wild-type and mutant HSCs, in which an environmental parameter α ∈ [0, 1] regulates death rates and interpolates between homeostatic (Moran...

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Literature Corpus work
e89e205d-b490-5fff-8912-9664118d0ada
DOI
10.64898/2026.01.27.702030
Open publication

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BESTish: A Diffusion-Approximation Framework for Inferring Selection and Mutation in Clonal HematopoiesisDOI 10.64898/2026.01.27.702030
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