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Article

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood.

Nature communications - 13 Aug 2021

Skead Kimberly, Ang Houle Armande, Abelson Sagi, Agbessi Mawusse, Bruat Vanessa, Lin Boxi, Soave David, Shlush Liran, Wright Stephen, Dick John, Morris Quaid, Awadalla Philip

Abstract excerpt

Age-related clonal hematopoiesis (ARCH) is characterized by age-associated accumulation of somatic mutations in hematopoietic stem cells (HSCs) or their pluripotent descendants. HSCs harboring driver mutations will be positively selected and cells carrying these mutations will rise in frequency. While ARCH is a known risk factor for blood malignancies, such as Acute Myeloid Leukemia (AML), why some people who...

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Identifiers

PMID: 34389724
DOI: 10.1038/s41467-021-25172-8
PMCID: PMC8363714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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