Article
Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood
2020-04-27
Abstract excerpt
A small population of self-renewing, hematopoietic stem cells continuously reconstitutes our immune system. As we age, these cells, or their pluripotent descendants, accumulate somatic mutations; some of these mutations provide selection advantages and increase in frequency in the peripheral blood cell population. This process of positive selection, deemed age-related clonal hematopoiesis (ARCH), is associated wit...
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Identifiers and source
- Literature Corpus work
- 6836d170-c99f-5ada-8428-a53cac3f9512
- DOI
- 10.1101/2020.04.25.058677