Article
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
2021-05-28
Abstract excerpt
The prevalence of clonal haematopoiesis of indeterminate potential (CHIP) in healthy individuals increases rapidly from age 60 onwards and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in stem cells that are also drivers of myeloid malignancies. Since mutations in stem cells often drive leukaemia, we hypothesised that stem cell fitnes...
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Identifiers and source
- Literature Corpus work
- 95cf9630-707a-5d75-b1d0-4c6e21815f13
- DOI
- 10.1101/2021.05.27.446006