Article
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects.
Nature medicine - 1 Jul 2022
Robertson Neil A, Latorre-Crespo Eric, Terradas-Terradas Maria, Lemos-Portela Jorge, Purcell Alison C, Livesey Benjamin J, Hillary Robert F, Murphy Lee, Fawkes Angie, MacGillivray Louise, Copland Mhairi, Marioni Riccardo E, Marsh Joseph A, Harris Sarah E, Cox Simon R, Deary Ian J, Schumacher Linus J, Kirschner Kristina, Chandra Tamir
Abstract excerpt
Clonal hematopoiesis of indeterminate potential (CHIP) increases rapidly in prevalence beyond age 60 and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in hematopoietic stem and progenitor cells (HSPCs). Because mutations in HSPCs often drive leukemia, we hypothesized that HSPC fitness substantially contributes to transformation from...
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