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Article

Mathematical modeling of JAK2V617F clonal expansion in a general population cohort.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2026

Snyder Jordan, Andersen Morten, Gudmand-Høyer Johanne, Larsen Morten Kranker, Skov Vibe, Kjær Lasse, Eickhardt-Dalbøge Christina Schjellerup, Knudsen Trine A, Ellervik Christina, Hasselbalch Hans C, Ottesen Johnny T, Stiehl Thomas

Abstract excerpt

The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are a group of blood cancers characterized by overproduction of one or more types of blood cells, which can lead to thrombosis and other complications. MPNs develop slowly and are driven by a relatively small set of mutations in the hematopoietic stem cells (HSCs). Their slow development (over the course of decades) affords a unique...

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Identifiers

PMID: 42308041
DOI: 10.1073/pnas.2507773123
PMCID: PMC13291664

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