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The dynamic fitness landscape of ageing haematopoiesis through clonal competition

2024-04-20

Abstract excerpt

Clonal haematopoiesis (CH) – the existence of large mutant clones in blood – is a prime example of somatic evolution. Yet how evolution shapes CH with age remains to be understood. Here, we show that clonal competition can explain the complex dynamics observed in vivo. In this paradigm, numerous fit clones continually appear and compete, driving an evolving fitness landscape of stem cells. This naturally explains...

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Identifiers and source

Literature Corpus work
2108be55-263f-53b8-ae88-802784245793
DOI
10.1101/2024.04.16.589764
Open publication

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The dynamic fitness landscape of ageing haematopoiesis through clonal competitionDOI 10.1101/2024.04.16.589764
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