Article
Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure
2025-03-02
Abstract excerpt
Clonal hematopoiesis (CH) is characterized by expanding blood cell clones carrying somatic mutations in healthy aged individuals and is associated with various age-related diseases and all-cause mortality. While CH mutations affect diverse genes associated with myeloid malignancies, their mechanisms of expansion and disease associations remain poorly understood. We investigate the relationship between clonal fitne...
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Identifiers and source
- Literature Corpus work
- c1766e64-64da-5c12-8888-34fdb0fa4bd8
- DOI
- 10.1101/2025.02.28.640879