Article
The evolutionary dynamics and fitness landscape of clonal hematopoiesis.
Science (New York, N.Y.) - 27 Mar 2020
Watson Caroline J, Papula A L, Poon Gladys Y P, Wong Wing H, Young Andrew L, Druley Todd E, Fisher Daniel S, Blundell Jamie R
Abstract excerpt
Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance remains largely unknown. Blood sequencing data from ~50,000 individuals reveal how mutation, genetic drift, and fitness shape the genetic diversity of healthy blood (clonal hematopoiesis). We show that positive selection, not drift,...
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