Article
Detecting and quantifying clonal selection in somatic stem cells
2021-12-16
Abstract excerpt
As DNA variants accumulate in somatic stem cells, become selected or evolve neutrally, they may ultimately alter tissue function. When, and how, selection occurs in homeostatic tissues is incompletely understood. Here, we introduce SCIFER, a scalable method that identifies selection in an individual tissue, without requiring knowledge of the underlying driver event. Moreover, SCIFER infers the self-renewal and mut...
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Identifiers and source
- Literature Corpus work
- 25162ec8-ebf9-522d-84c3-c8410d4cfb15
- DOI
- 10.1101/2021.12.15.472780