Article
The evolutionary dynamics and fitness landscape of clonal haematopoiesis
2019-03-06
Abstract excerpt
Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance, however, remains largely unknown. Here, by combining blood sequencing data from ∼50,000 individuals, we reveal how mutation, genetic drift and fitness differences combine to shape the genetic diversity of healthy blood (‘clonal haema...
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Identifiers and source
- Literature Corpus work
- bc5ffe83-1ce5-5c47-b8e8-d94c872aae56
- DOI
- 10.1101/569566