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The age-related deceleration of clonal haematopoiesis in 420,000 healthy adults

2023-12-21

Abstract excerpt

Somatic mutations acquired in haematopoietic stem cells can drive clonal expansions, a phenomenon known as clonal haematopoiesis (CH). CH has been associated with higher risk of haematological cancer, cardiovascular disease and lower life expectancy and is strongly age-dependent, becoming almost ubiquitous in older adults. However, the dynamics of CH are not yet fully understood, and an accurate quantitative model...

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Literature Corpus work
ee760131-6a1e-51e1-8d2b-c879ecd4d834
DOI
10.1101/2023.12.21.572706
Open publication

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The age-related deceleration of clonal haematopoiesis in 420,000 healthy adultsDOI 10.1101/2023.12.21.572706
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