Article

Estimating single cell clonal dynamics in human blood using coalescent theory

2023-02-27

Abstract excerpt

While evolutionary approaches to medicine show promise, measuring evolution itself is difficult due to experimental constraints and the dynamic nature of body systems. In cancer evolution, continuous observation of clonal architecture is impossible, and longitudinal samples from multiple timepoints are rare. Increasingly available DNA sequencing datasets at single cell resolution enable the reconstruction of past...

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Literature Corpus work: fa6e4413-1405-521a-b4d7-4435703f9540
DOI: 10.1101/2023.02.24.529817

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