Article

A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation

2024-10-30

Abstract excerpt

Epigenetic regulation involves the coordinated interplay of diverse proteins. To systematically explore these combinations, we present COMBINE (combinatorial interaction exploration), a high-throughput platform that tests over 50,000 pairs of epigenetic effector domains up to 2,094 amino acids in length for their ability to modulate endogenous human gene transcription. COMBINE revealed diverse synergistic and anta...

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Identifiers and source

Literature Corpus work: e8619e3f-b92b-57ff-b7ec-d9e89352fcec
DOI: 10.1101/2024.10.28.620683

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