Article

High-throughput functional characterization of combinations of transcriptional activators and repressors

2022-12-20

Abstract excerpt

Despite growing knowledge of the functions of individual human transcriptional effector domains, much less is understood about how multiple effector domains within the same protein combine to regulate gene expression. Here, we measure transcriptional activity for 8,400 effector domain combinations by recruiting them to reporter genes in human cells. In our assay, weak and moderate activation domains synergize to d...

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Literature Corpus work: 48406be8-4509-5e13-a5f5-17a9b8642c6f
DOI: 10.1101/2022.12.20.521091

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