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BRD4, Mediator, and Pol II form heterogeneous condensates with distinct transcriptional and acetylation-dependent states

2026-06-08

Abstract excerpt

Transcriptional condensates at super-enhancers are thought to concentrate BRD4, Mediator, and RNA polymerase II (Pol II) to promote gene activation, yet their compositional organization and regulation remain poorly understood. We developed a high-throughput live-cell phenomics platform based on endogenous fluorescent tagging of BRD4, MED14 (Mediator), and POLR2A (Pol II) to systematically quantify transcriptional...

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Literature Corpus work
7f1c748e-0822-5670-b935-c1f8166a5bcc
DOI
10.64898/2026.06.04.729043
Open publication

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BRD4, Mediator, and Pol II form heterogeneous condensates with distinct transcriptional and acetylation-dependent statesDOI 10.64898/2026.06.04.729043
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