Article

High-throughput discovery and characterization of human transcriptional effectors

2020-09-10

Abstract excerpt

<h4>Summary</h4> Thousands of proteins localize to the nucleus; however, it remains unclear which contain transcriptional effectors. Here, we develop HT-recruit - a pooled assay where protein libraries are recruited to a reporter, and their transcriptional effects are measured by sequencing. Using this approach, we measure gene silencing and activation for thousands of domains. We find a relationship between repr...

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Literature Corpus work: 1863921d-3035-5b51-80b4-b97b692844e9
DOI: 10.1101/2020.09.09.288324

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