Article

Scalable pooled CRISPR screens with single-cell chromatin accessibility profiling

2020-11-20

Abstract excerpt

Pooled CRISPR screens have been used to identify genes responsible for specific phenotypes and diseases, and, more recently, to connect genetic perturbations with multi-dimensional gene expression profiles. Here, we describe a method to link genome-wide chromatin accessibility to genetic perturbations in single cells. This scalable, cost-effective method combines pooled CRISPR perturbations with a single-cell comb...

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Literature Corpus work: 93fbf7f8-6780-5eb7-9c4a-bf5895da7b1a
DOI: 10.1101/2020.11.20.390971

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