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A toolkit for programmable transcriptional engineering across eukaryotic kingdoms

2026-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin is essential for eukaryotic life. Tens of thousands of chromatin regulator (CR) proteins exist in eukaryotic genomes that are predicted to modulate chromatin states; however, their molecular functions remain largely untested experimentally. Here, we construct a library of over 300 full-length CRs from humans, plants, yeast, protozoa, and virus, each fused to DNA-binding domains, and te...

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Literature Corpus work
631ef2f3-2be2-5332-8b7d-db25e841c8da
DOI
10.64898/2026.02.10.705154
Open publication

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A toolkit for programmable transcriptional engineering across eukaryotic kingdomsDOI 10.64898/2026.02.10.705154
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