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Discovery and engineering of hypercompact epigenetic modulators for durable gene activation

2023-06-08

Abstract excerpt

<title>Abstract</title> <p>Transcriptional and epigenetic regulators shape the chromatin microenvironment and corresponding gene expression during cellular differentiation and homeostasis. Programmable modulators of transcription provide a powerful toolkit for controlling gene dosage in therapeutic applications, but a limited catalog of functional domains constrains their robustness and durability profiles, and l...

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Literature Corpus work
a9f46996-b986-5203-86ce-ea7ac4ebf56c
DOI
10.21203/rs.3.rs-3016082/v1
Open publication

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Discovery and engineering of hypercompact epigenetic modulators for durable gene activationDOI 10.21203/rs.3.rs-3016082/v1
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