Article

Large-scale mapping and systematic mutagenesis of human transcriptional effector domains

2022-08-26

Abstract excerpt

<h4>Summary</h4> Human gene expression is regulated by over two thousand transcription factors and chromatin regulators 1,2 . Effector domains within these proteins can activate or repress transcription. However, for many of these regulators we do not know what type of transcriptional effector domains they contain, their location in the protein, their activation and repression strengths, and the amino acids that...

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Literature Corpus work: 158450aa-c42f-55d5-a897-ff8dc5132caa
DOI: 10.1101/2022.08.26.505496

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