Article

Discovery of hypercompact epigenetic modulators for persistent CRISPR-mediated gene activation

2023-06-03

Abstract excerpt

Programmable epigenetic modulators provide a powerful toolkit for controlling gene expression in novel therapeutic applications, but recent discovery efforts have primarily selected for potency of effect rather than contextual robustness or durability thereof. Current CRISPR-based tools are further limited by large cargo sizes that impede clinical delivery and, in gene activation contexts, by brief activity window...

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Literature Corpus work: 1da07196-f4bf-55f5-a0b9-ed7ba708007f
DOI: 10.1101/2023.06.02.543492

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