Article

Genetic determinants of chromatin accessibility in T cell activation across humans

2016-12-02

Abstract excerpt

Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation in health and disease. One possible mechanism is that genetic variants affect the activity of one or more cis -regulatory elements leading to gene expression variation in specific cell types. To identify such cases, we analyzed Assay for Transposase-Accessib...

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Literature Corpus work: 63f62f14-4022-5423-9b48-1fbd744f6e2c
DOI: 10.1101/090241

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