Article
Integration of genetic and chromatin modification data pinpoints autoimmune-specific remodeling of enhancer landscape in CD4+ T cells.
Cell reports - 22 Oct 2024
Daga Neha, Servaas Nila H, Kisand Kai, Moonen Dewi, Arnold Christian, Reyes-Palomares Armando, Kaleviste Epp, Kingo Külli, Kuuse Reet, Ulst Katrin, Steinmetz Lars, Peterson Pärt, Nakic Nikolina, Zaugg Judith B
Abstract excerpt
CD4+ T cells play a crucial role in adaptive immune responses and have been implicated in the pathogenesis of autoimmune diseases (ADs). Despite numerous studies, the molecular mechanisms underlying T cell dysregulation in ADs remain incompletely understood. Here, we used chromatin immunoprecipitation (ChIP)-sequencing of active chromatin and transcriptomic data from CD4+ T cells of healthy donors and patients...
Topics
- Humans
- CD4-Positive T-Lymphocytes
- Enhancer Elements, Genetic
- Chromatin
- Polymorphism, Single Nucleotide
- Autoimmune Diseases
- Gene Regulatory Networks
- Chromatin Assembly and Disassembly
- Autoimmunity