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Article

Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci.

Genome biology - 10 Feb 2025

Shi Chenfu, Zhao Danyun, Butler Jake, Frantzeskos Antonios, Rossi Stefano, Ding James, Ferrazzano Carlo, Wynn Charlotte, Hum Ryan Malcolm, Richards Ellie, Gupta Muskan, Patel Khadijah, Yap Chuan Fu, Plant Darren, Grencis Richard, Martin Paul, Adamson Antony, Eyre Stephen, Bowes John, Barton Anne, Ho Pauline, Rattray Magnus, Orozco Gisela

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have uncovered the genetic basis behind many diseases and conditions. However, most of these genetic loci affect regulatory regions, making the interpretation challenging. Chromatin conformation has a fundamental role in gene regulation and is frequently used to associate potential target genes to regulatory regions. However, previous studies mostly used small...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39930543
DOI: 10.1186/s13059-025-03492-y
PMCID: PMC11808986

Genes

ACOXL
BCL2L11
CD4
CTCF
SESN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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