Article

Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cells

2024-10-12

Abstract excerpt

Genetic variants associated with autoimmune diseases are highly enriched within putative cis -regulatory regions of CD4 + T cells, suggesting that they alter disease risk via changes in gene regulation. However, very few genetic variants have been shown to affect T cell gene expression or function. We tested >18,000 autoimmune disease-associated variants for allele-specific expression using massively parallel re...

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Literature Corpus work: ebbda6f9-d296-5bf0-bf34-34afa3c9d0d1
DOI: 10.1101/2024.10.07.617092

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