Article
Whole genome analysis of the methylome and hydroxymethylome in normal and malignant lung and liver
2016-07-10
Abstract excerpt
DNA methylation at the 5-postion of cytosine (5mC) is a well-established epigenetic modification which regulates gene expression and cellular plasticity in development and disease. The ten-eleven translocation (TET) gene family is able to oxidize 5mC to 5-hydroxymethyl-cytosine (5hmC), providing an active mechanism for DNA demethylation, and may also provide its own regulatory function. Here we applied oxidative b...
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Identifiers and source
- Literature Corpus work
- e83e00e9-d79d-5d0d-8a1c-32f836098220
- DOI
- 10.1101/062588