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Article

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.

Molecular cell - 18 Aug 2016

Han Dali, Lu Xingyu, Shih Alan H, Nie Ji, You Qiancheng, Xu Meng Michelle, Melnick Ari M, Levine Ross L, He Chuan

Abstract excerpt

We present a highly sensitive and selective chemical labeling and capture approach for genome-wide profiling of 5-hydroxylmethylcytosine (5hmC) using DNA isolated from ∼1,000 cells (nano-hmC-Seal). Using this technology, we assessed 5hmC occupancy and dynamics across different stages of hematopoietic differentiation. Nano-hmC-Seal profiling of purified Tet2-mutant acute myeloid leukemia (AML) murine stem cells...

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Identifiers

PMID: 27477909
DOI: 10.1016/j.molcel.2016.06.028
PMCID: PMC4992443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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