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Article

Multifaceted Roles of DNA Methylation in Neoplastic Transformation, from Tumor Suppressors to EMT and Metastasis.

Genes - 12 Aug 2020

Casalino Laura, Verde Pasquale

Abstract excerpt

Among the major mechanisms involved in tumorigenesis, DNA methylation is an important epigenetic modification impacting both genomic stability and gene expression. Methylation of promoter-proximal CpG islands (CGIs) and transcriptional silencing of tumor suppressors represent the best characterized epigenetic changes in neoplastic cells. The global cancer-associated effects of DNA hypomethylation influence...

Topics

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Cell Transformation, Neoplastic
CpG Islands
DNA (Cytosine-5-)-Methyltransferases
Epithelial-Mesenchymal Transition
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Neoplastic Stem Cells

RNA Interference

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Identifiers

PMID: 32806509
DOI: 10.3390/genes11080922
PMCID: PMC7463745

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