Article
Roles and Regulations of TET Enzymes in Solid Tumors.
Trends in cancer - 1 Jul 2021
Bray Julie K, Dawlaty Meelad M, Verma Amit, Maitra Anirban
Abstract excerpt
The mechanisms governing the methylome profile of tumor suppressors and oncogenes have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven translocation (TET) enzymes are a family of dioxygenases that iteratively catalyze 5mC oxidation and promote cytosine demethylation, thereby creating a dynamic global and local methylation landscape. While the catalytic function of TET enzymes...
Topics
- 5-Methylcytosine
- Antineoplastic Combined Chemotherapy Protocols
- Carcinogenesis
- Clinical Trials as Topic
- DNA Methylation
- DNA-Binding Proteins
- Dioxygenases
- Drug Synergism
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic