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Article

High-throughput sequencing offers new insights into 5-hydroxymethylcytosine.

Biomolecular concepts - 1 Jun 2016

Pang Alina P S, Sugai Christopher, Maunakea Alika K

Abstract excerpt

Chemical modifications of DNA comprise epigenetic mechanisms that contribute to the maintenance of cellular activities and memory. Although the function of 5-methylcytosine (5-mC) has been extensively studied, little is known about the function(s) of relatively rarer and underappreciated cytosine modifications including 5-hydroxymethylcytosine (5-hmC). The discovery that ten-eleven translocation (Tet) proteins...

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5-Methylcytosine
Cytosine
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

High-Throughput Nucleotide Sequencing

Organ Specificity

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Identifiers

PMID: 27356236
DOI: 10.1515/bmc-2016-0011
PMCID: PMC5433849

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