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Article

Epigenomic analysis of 5-hydroxymethylcytosine (5hmC) reveals novel DNA methylation markers for lung cancers.

Neoplasia (New York, N.Y.) - 1 Mar 2020

Wang Zhihui, Du Mulong, Yuan Qianyu, Guo Yichen, Hutchinson John N, Su Li, Zheng Yinan, Wang Jun, Mucci Lorelei A, Lin Xihong, Hou Lifang, Christiani David C

Abstract excerpt

BACKGROUND: DNA methylation at the fifth position of cytosine (5mC) is a common epigenetic alteration affecting a range of cellular processes. In recent years, 5-hydroxymethylcytosine (5hmC), an oxidized form of 5mC, has risen broad interests as a potential biomarker for lung cancer diagnosis and survival. METHODS: We analyzed the epigenome-wide 5hmC profiles of paired lung tumor and adjacent normal tissues,...

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Identifiers

PMID: 32062069
DOI: 10.1016/j.neo.2020.01.001
PMCID: PMC7021546

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