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Article

Tissue-specific 5-hydroxymethylcytosine landscape of the human genome.

Nature communications - 12 Jul 2021

He Bo, Zhang Chao, Zhang Xiaoxue, Fan Yu, Zeng Hu, Liu Jun'e, Meng Haowei, Bai Dongsheng, Peng Jinying, Zhang Qian, Tao Wei, Yi Chengqi

Abstract excerpt

5-Hydroxymethylcytosine (5hmC) is an important epigenetic mark that regulates gene expression. Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues. We found that 5hmC preferentially decorates gene bodies and outperforms gene body 5mC in...

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Identifiers

PMID: 34253716
DOI: 10.1038/s41467-021-24425-w
PMCID: PMC8275684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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