Article

Locus-specific enrichment analysis of 5-hydroxymethylcytosine reveals novel genes associated with breast carcinogenesis

2022-06-19

Abstract excerpt

<h4>Background</h4> An imbalance in DNA methylation is a hallmark epigenetic alteration in cancer. The conversion of 5-methylcytosine (5-mC) to 5-hydroxymethyl cytosine (5-hmC), which causes the imbalance, results in aberrant gene expression. The precise functional role of 5-hydroxymethylcytosine in breast cancer remains elusive. In this study, we describe the landscape of 5-mC and 5-hmC and their association wit...

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Literature Corpus work: 84557363-131b-595b-bf22-0ebd68ce52d8
DOI: 10.1101/2022.06.17.496656

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