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Article

5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer.

Biochimica et biophysica acta - 1 Apr 2015

Kroeze Leonie I, van der Reijden Bert A, Jansen Joop H

Abstract excerpt

The epigenetic mark 5-hydroxymethylcytosine (5hmC) has gained interest since 2009, when it was discovered that Ten-Eleven-Translocation (TET) proteins catalyze the conversion of 5-methylcytosine (5mC) into 5hmC. This conversion appears to be an intermediate step in the active DNA demethylation pathway. Factors that regulate DNA hydroxymethylation are frequently affected in cancer, leading to deregulated 5hmC...

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Identifiers

PMID: 25579174
DOI: 10.1016/j.bbcan.2015.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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