Article
Global DNA methylomes reveal oncogenic-associated 5-hydroxylmethylated cytosine (5hmC) signatures in the cell-free DNA of cancer patients
2025-01-15
Abstract excerpt
Characterization of tumor epigenetic aberrations is integral to understanding the mechanisms of tumorigenesis and provide diagnostic, prognostic, and predictive information of high clinical relevance. Among the different tumor-associated epigenetic signatures, 5 methyl-cytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the two most well-characterized DNA methylation alterations linked to cancer pathogenesis. 5h...
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Identifiers and source
- Literature Corpus work
- a8e916ee-23b0-5348-b923-e0ecefb2cd56
- DOI
- 10.1101/2025.01.09.25320283