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5-Hydroxymethylcytosine: a key epigenetic mark in cancer and chemotherapy response

17 Nov 2025

Abstract excerpt

5-hydroxymethylcytosine (5hmC), an epigenetic modification derived from the oxidation of 5-methylcytosine (5mC) by the ten-eleven translocation (TET) family of dioxygenases, plays a pivotal role in the regulation of gene expression, cellular differentiation, and developmental plasticity. Once considered an intermediate in DNA demethylation, 5hmC is now recognized as a stable and functionally significant...

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PMID: 41243111
DOI: 10.1186/s13072-025-00636-z

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