Article
New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation
2018-05-30
Abstract excerpt
Many DNA methylome profiling methods cannot distinguish between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Since 5mC typically acts as a repressive mark whereas 5hmC is an intermediate form during active demethylation, the inability to separate their signals could lead to incorrect interpretation of the data. Meanwhile, many analysis pipelines quantify methylation level by the count or ratio of met...
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Identifiers and source
- Literature Corpus work
- 1929b784-e7ad-5bc9-8f9c-4763610c8e09
- DOI
- 10.1101/334318