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Article

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.

Nature genetics - 1 Nov 1999

Lyko F, Ramsahoye B H, Kashevsky H, Tudor M, Mastrangelo M A, Orr-Weaver T L, Jaenisch R

Abstract excerpt

CpG methylation is essential for mouse development as well as gene regulation and genome stability. Many features of mammalian DNA methylation are consistent with the action of a de novo methyltransferase that establishes methylation patterns during early development and the post-replicative maintenance of these patterns by a maintenance methyltransferase. The mouse methyltransferase Dnmt1 (encoded by Dnmt) shows...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10545955
DOI: 10.1038/15551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.PMID 10545955Read ↗

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Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem CellsSemantic proximity Read ↗

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