Article

DNMT1 overexpression disrupts DNA methylation homeostasis in mouse embryonic stem cells

2026-01-28

Abstract excerpt

DNMT1 overexpression is frequently observed in cancer and other pathologies, yet its direct impact on DNA methylation remains poorly defined. Using whole-genome methyl sequencing, we show that overexpressing DNMT1 in mouse embryonic stem cells (mESCs) induces global hypomethylation, focal hypermethylation in promoters and CpG islands, and increased methylome variability—well-documented characteristics of cancer. W...

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Literature Corpus work: 0d567870-3770-5be4-9393-6ca903d59e21
DOI: 10.64898/2026.01.26.701550

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