Article

Mouse embryonic stem cells exhibit cancer-like DNA methylation landscapes upon DNMT1 overexpression

2026-04-02

Abstract excerpt

<title>Abstract</title> <p>DNA methyltransferase 1 (DNMT1) overexpression is a recurrent feature and an emerging therapeutic target in cancer, yet its direct impact on DNA methylation regulation remains poorly defined. Using enzymatic methyl sequencing, we show that DNMT1 overexpression in mouse embryonic stem cells leads to DNA methylation landscapes strikingly reminiscent of cancer methylomes, characterized by...

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Literature Corpus work: 15adc2c6-d0c6-533c-9ce8-c13e49e47de1
DOI: 10.21203/rs.3.rs-9052961/v1

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