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Article

DNA methylation dynamics of genomic imprinting in mouse development†

15 Feb 2018

Abstract excerpt

DNA methylation is an essential epigenetic mark crucial for normal mammalian development. This modification controls the expression of a unique class of genes, designated as imprinted, which are expressed monoallelically and in a parent-of-origin-specific manner. Proper parental allele-specific DNA methylation at imprinting control regions (ICRs) is necessary for appropriate imprinting. Processes that deregulate...

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Share to Epigenetics and DNA Methylation
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PMID: 29462489
DOI: 10.1093/biolre/ioy036

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