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Article

Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2009

Borowczyk Ewa, Mohan K Naga, D'Aiuto Leonardo, Cirio M Cecilia, Chaillet J Richard

Abstract excerpt

Reprogramming of DNA methylation patterns during mammalian preimplantation development involves the concurrent maintenance of methylation on differentially methylated domains (DMDs) of imprinted genes and a marked reduction of global (non-DMD) genomic methylation. In the developing mammalian embryo, one allele of a DMD is unmethylated, and the opposite parental allele is methylated, having inherited this...

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Source

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Identifiers

PMID: 19923434
DOI: 10.1073/pnas.0905668106
PMCID: PMC2791569

Genes

DMD
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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